From the disease of “gay people and drug addicts” to the “Millennium Plague” capable of affecting everyone without distinction. Estimates made on the basis of data provided by the Ministry of Health indicate that in Italy there are currently 170,000-180,000 living HIV-positive people, of which about 22,000 infected with AIDS, however one in four HIV-positive does not know that they are infected. From the information gathered by the surveillance systems, it appears that the characteristics of those who become infected with HIV today are completely different from those who became infected ten or twenty years ago. They are no longer young people and predominantly drug addicts, but rather mature adults who become infected through unprotected sexual relationship (mostly heterosexual). Therefore, the average age of people who contract the virus changes, which now exceeds 40 years, with an increase among women that represent half of the patients. Since 1997 there has been a progressive decline in deaths, which in 2007 were about 200, a consequence of the new antiretroviral therapies, which have contributed to transforming AIDS into a chronic disease. Today people infected with AIDS go to school, go to work, we can make plans for the future. Thanks to medical drugs the life expectancy increased from twenty to thirty years. Carmela was born on 3 July 1959 in Delianuova, a small town closed to Reggio Calabria. She spends a few years in Leverkusen, Germany, and then moves to Acqui Terme after her marriage. Her two children Francesco (30 years) and Marisol (25 years) will be born there. In 1986 Carmela contracted the HIV virus following a relationship with her brother-in-law, with whom she will spend the next ten years of her life. It is only in 1996 that Carmela discovers to be HIV-positive and a year later, following the death of her partner due to the degeneration of the disease, the thought of her children encourages her to start the cycle of treatment. After spending the last seven years as a guest in a family home for people with AIDS, Carmela currently lives in Rome with her daughter Marisol.